SMG6

Across TCGA patient cohorts, SMG6 mutation is significantly associated with the RNA expression of many other genes, with 6,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG6-associated genes across cancer lineages are RNU6-178P, TRMU, and GSKIP. Each is linked with SMG6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG6-to-partner and partner-to-SMG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-178P grouped by SMG6-low versus SMG6-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG6→partner) and Y-score (partner→SMG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-178P →	+0.578	+4.361	<.001	.006	3	3
UCEC	TRMU →	+0.543	+2.321	<.001	<.001	3	3
UCEC	GSKIP →	+0.540	+2.087	<.001	<.001	3	3
COAD	GPR143 →	-1.550	-3.793	<.001	<.001	3	3
UCEC	PRPS2 →	+0.559	+1.874	<.001	<.001	3	3
UCEC	PGK1 →	+0.824	+2.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,330 associations by consensus.

RNU6-178P by SMG6 expression — READ

Explore this box plot interactively →