SMG6-IT1

Across TCGA pan-cancer cohorts, SMG6-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SMG6-IT1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SMG6-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMG6-IT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KICH, LIHC, and DLBC are the cancer types where SMG6-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.033	0.893	<.001	105	view →
LIHC	DFS	Tertile	III,IV	0.076	0.360	.001	72	view →
DLBC	DFS	Tertile	III,IV	0.068	0.765	<.001	63	view →
UVM	DFS	Tertile	All	0.267	0.783	.001	36	view →
PCPG	DFS	Tertile	All	0.440	0.894	.002	33	view →
THYM	OS	Tertile	III,IV	0.212	0.953	.009	27	view →
SKCM	DFS	Tertile	II,III,IV	0.786	0.207	.004	24	view →
SARC	OS	Tertile	All	0.226	0.565	<.001	24	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
TGCT	OS	Tertile	All	0.920	0.992	.021	18	view →
UCS	OS	Tertile	All	0.187	0.583	.047	18	view →
LUAD	DFS	Tertile	II,III,IV	0.680	0.227	.025	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SMG6-IT1–KICH (DFS)

Open the KICH breakdown →