SMG6-IT1

Across TCGA pan-cancer cohorts, SMG6-IT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SMG6-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SMG6-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types SMG6-IT1 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, STAD, and KICH are the cancer types where SMG6-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMG6-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.067	.045	2	view →
STAD	Male	II,III,IV	+0.116	.032	1	view →
KICH	All	All	−0.045	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SMG6-IT1–BRCA

Open the BRCA breakdown →