Across TCGA cell cohorts, SMG5 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMG5-associated genes across cancer lineages are NXPE4, CYLC1, and GHRHR. Each is linked with SMG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG5-to-partner and partner-to-SMG5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG5→partner) and Y-score (partner→SMG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NXPE4 →	+0.011	+3.428	.001	<.001	3	2
PANCREAS	CYLC1 →	+0.006	+5.614	<.001	.002	3	1
BLOOD_Leukemia	GHRHR →	+0.266	+3.121	<.001	.003	3	1
BLOOD_Leukemia	LIFR →	+0.713	+3.504	<.001	.004	3	1
BLOOD_Leukemia	TNP1 →	+0.083	+3.984	<.001	.006	3	1
BLOOD_Leukemia	TEKT3 →	+0.244	+3.553	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

SMG5 survival (RNA) · tumor vs normal (RNA) · all SMG5 data types