SMG1

Across TCGA patient cohorts, SMG1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,948 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SMG1-associated genes across cancer lineages are AUNIP, KIF18A, and TOP2A. Each is linked with SMG1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMG1 versus AUNIP in UCEC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AUNIP →	+0.919	+0.193	<.001	.003	3	8
BRCA	KIF18A →	+0.785	+0.166	.001	<.001	3	7
BRCA	TOP2A →	+1.051	+0.153	.002	.001	3	7
LSCC	CDCA8 →	+0.845	+0.134	<.001	<.001	3	7
BRCA	PLK1 →	+0.957	+0.195	<.001	<.001	3	7
UCEC	DEPDC1 →	+1.001	+0.192	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,948 associations by consensus.

SMG1 vs AUNIP — UCEC

Explore this scatter interactively →