SMCR8

Across TCGA patient cohorts, SMCR8 mutation is significantly associated with the RNA expression of many other genes, with 3,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCR8-associated genes across cancer lineages are RNU6-933P, STRIP2, and NOS2P2. Each is linked with SMCR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMCR8-to-partner and partner-to-SMCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-933P grouped by SMCR8-low versus SMCR8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCR8→partner) and Y-score (partner→SMCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-933P →	+0.483	+2.844	<.001	.009	3	3
UCEC	STRIP2 →	+0.532	+3.169	<.001	<.001	3	3
LUAD	NOS2P2 →	+0.625	+4.628	<.001	.004	3	3
SKCM	RNA5SP426 →	+0.224	+5.900	<.001	<.001	3	3
UCEC	HOMER1 →	+0.565	+1.754	<.001	.001	3	2
UCEC	FLCN →	+0.494	+3.180	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,067 associations by consensus.

RNU6-933P by SMCR8 expression — BLCA

Explore this box plot interactively →