SMCP

Across TCGA patient cohorts, SMCP mutation is significantly associated with the RNA expression of many other genes, with 330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCP-associated genes across cancer lineages are CHCHD2P11, RN7SL726P, and PRAMEF28P. Each is linked with SMCP in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCP-to-partner and partner-to-SMCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD2P11 grouped by SMCP-low versus SMCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCP→partner) and Y-score (partner→SMCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD2P11 →	+0.334	+3.120	.001	.001	3	1
UCEC	RN7SL726P →	+0.197	+3.225	<.001	<.001	3	1
UCEC	PRAMEF28P →	+0.066	+3.136	.001	.007	3	1
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	1
UCEC	ELMO2P1 →	+0.246	+4.017	<.001	<.001	3	1
UCEC	MIR8055 →	+0.636	+2.544	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

CHCHD2P11 by SMCP expression — UCEC

Explore this box plot interactively →