SMCP

Across TCGA pan-cancer cohorts, SMCP RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SMCP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMCP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMCP is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where SMCP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMCP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.146	.005	7	view →
LUSC	All	All	+0.573	<.001	6	view →
BLCA	Male	All	+0.192	.030	2	view →
STAD	All	All	−0.037	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SMCP–HNSC

Open the HNSC breakdown →