SMCP

Across TCGA patient cohorts, SMCP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCP-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and Rab25. Each is linked with SMCP in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCP-to-partner and partner-to-SMCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMCP-low versus SMCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCP→partner) and Y-score (partner→SMCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-3.000	.039	.036	3	1
UCEC	eIF4G →	+0.366	+3.000	.041	.037	3	1
UCEC	Rab25 →	-0.452	-3.000	.018	.037	3	1
UCEC	Tuberin →	+0.384	+3.009	.013	.019	3	1
UCEC	C-Raf →	+0.213	+3.000	.010	.037	3	1
UCEC	eIF4E →	+0.268	+3.000	.028	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by SMCP expression — UCEC

Explore this box plot interactively →