SMCP

Across TCGA cell cohorts, SMCP RNA expression is significantly associated with the mutation status of many other genes, with 126 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMCP-associated genes across cancer lineages are SHANK1, SLC28A1, and INTS8. Each is linked with SMCP in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCP-to-partner and partner-to-SMCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHANK1 grouped by SMCP-low versus SMCP-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCP→partner) and Y-score (partner→SMCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SHANK1 →	+5.369	+0.136	.004	<.001	3	2
CNS	SLC28A1 →	+5.321	+0.197	.005	<.001	3	2
BREAST	INTS8 →	+5.169	+0.068	.005	<.001	3	2
BLOOD_Lymphoma	SCN1A →	+3.130	+0.024	.006	<.001	3	2
BLOOD_Lymphoma	NCK1 →	+4.867	+0.030	.009	.001	3	2
LUNG_SCLC	FER1L6 →	+4.058	+0.038	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

SHANK1 by SMCP expression — SOFT_TISSUE

Explore this box plot interactively →