SMC6

Across TCGA patient cohorts, SMC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,703 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC6-associated proteins across cancer lineages are MCM3, MCM5, and MCM7. Each is linked with SMC6 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMC6 versus MCM3 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM3 →	+0.653	+0.343	<.001	<.001	3	9
GBM	MCM5 →	+0.624	+0.315	<.001	.001	3	9
OV	MCM7 →	+0.689	+0.552	.001	<.001	3	8
GBM	MCM2 →	+0.652	+0.354	<.001	<.001	3	8
LUAD	MCM2_S139 →	+0.571	+0.306	<.001	<.001	3	8
OV	MCM4 →	+0.693	+0.559	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,703 associations by consensus.

SMC6 vs MCM3 — GBM

Explore this scatter interactively →