Q-omics provides the consensus-scored SMC3P1 profile across patient tissues and cancer cell-line models. SMC3P1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, SMC3P1 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, SMC3P1 RNA expression shows 19,766 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BLCA, KIRC, and THYM as cancer lineages where SMC3P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SMC3P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SMC3P1 survival associations across molecular data types. SMC3P1 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SMC3P1 RNA expression–survival associations across cancer types. High SMC3P1 expression shows favorable associations in BLCA, HNSC, KIRC, UCS, THYM and LAML. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BLCA as the clearest survival context for SMC3P1 RNA expression.
This table summarizes SMC3P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for SMC3P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SMC3P1 shows lower tumor expression in KIRC, THCA and KICH and higher tumor expression in COAD, STAD and LIHC. The KIRC box plot shows higher SMC3P1 RNA expression in normal versus tumor tissue (log2 FC = −0.610, t-test p < 0.001).
This table shows molecular features associated with SMC3P1 in patient tissues and cancer cell lines. In patient samples, SMC3P1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
