SMC3

Across TCGA cell cohorts, SMC3 mutation is significantly associated with the RNA expression of many other genes, with 489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC3-associated genes across cancer lineages are OR8D1, OR8B2, and SPATA19. Each is linked with SMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC3-to-partner and partner-to-SMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D1 grouped by SMC3-low versus SMC3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC3→partner) and Y-score (partner→SMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR8D1 →	+0.045	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	OR8B2 →	+0.033	+6.247	<.001	<.001	3	2
KIDNEY	SPATA19 →	+0.036	+5.000	<.001	.005	3	1
KIDNEY	CT47B1 →	+0.023	+5.000	<.001	.005	3	1
OESOPHAGUS	OR1Q1 →	+0.169	+3.523	<.001	.009	3	1
OESOPHAGUS	CDR1 →	+0.148	+3.392	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

OR8D1 by SMC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →