SMC2

Across TCGA patient cohorts, SMC2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC2-associated genes across cancer lineages are HER3_pY1289, eIF4E, and p62 Lck ligand. Each is linked with SMC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC2-to-partner and partner-to-SMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by SMC2-low versus SMC2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC2→partner) and Y-score (partner→SMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HER3_pY1289 →	+0.140	+3.000	.025	.036	3	2
UCEC	eIF4E →	+0.152	+3.472	.020	.002	3	2
UCEC	p62 Lck ligand →	+0.246	+1.775	.014	.007	3	2
UCEC	Rad50 →	-0.197	-2.308	.008	.005	3	2
UCEC	VHL →	-0.793	-1.643	<.001	.003	3	2
UCEC	ASNS →	+0.401	+1.321	<.001	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

HER3_pY1289 by SMC2 expression — BLCA

Explore this box plot interactively →