SMC2

Across TCGA pan-cancer cohorts, SMC2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SMC2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMC2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where SMC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.413	<.001	11	view →
BLCA	All	III,IV	+1.344	<.001	11	view →
STAD	Female	All	+1.724	<.001	10	view →
LIHC	Female	II,III,IV	+1.349	<.001	9	view →
LUSC	Female	All	+1.828	<.001	8	view →
BRCA	All	III,IV	+0.787	<.001	8	view →
COAD	Male	All	+0.780	<.001	8	view →
LUAD	Male	II,III,IV	+0.970	<.001	7	view →
UCEC	All	All	+0.745	.015	6	view →
CHOL	Male	All	+2.186	<.001	5	view →
ESCA	All	All	+1.398	<.001	5	view →
READ	All	All	+0.617	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SMC2–HNSC

Open the HNSC breakdown →