SMC2

Across TCGA cell cohorts, SMC2 mutation is significantly associated with the RNA expression of many other genes, with 898 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC2-associated genes across cancer lineages are RBMXL2, FANCD2OS, and TMED2. Each is linked with SMC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMC2-to-partner and partner-to-SMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMXL2 grouped by SMC2-low versus SMC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC2→partner) and Y-score (partner→SMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBMXL2 →	+0.054	+2.632	.001	.008	3	3
LARGE_INTESTINE	FANCD2OS →	+0.101	+2.497	<.001	.002	3	2
LARGE_INTESTINE	TMED2 →	+0.397	+3.321	.007	.003	3	2
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	2
LARGE_INTESTINE	GCAT →	+1.458	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.531	+3.237	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 898 associations by consensus.

RBMXL2 by SMC2 expression — LARGE_INTESTINE

Explore this box plot interactively →