SMC2-AS1

Across TCGA pan-cancer cohorts, SMC2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SMC2-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SMC2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMC2-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.

ACC, KIRC, and LIHC are the cancer types where SMC2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.432	0.772	<.001	88	view →
KIRC	DFS	Quartile	II,III,IV	0.346	0.630	<.001	77	view →
LIHC	DFS	Quartile	All	0.456	0.646	<.001	48	view →
PAAD	OS	Quartile	All	0.668	0.359	<.001	42	view →
HNSC	DFS	Tertile	IV	0.727	0.569	.005	38	view →
BLCA	OS	Median	All	0.773	0.660	.003	36	view →
UCEC	DFS	Median	III,IV	0.719	0.443	.006	36	view →
THYM	DFS	Tertile	All	0.950	0.610	.013	23	view →
UCS	DFS	Quartile	III,IV	0.534	0.166	.014	22	view →
MESO	OS	Quartile	II,III,IV	0.535	0.279	.002	19	view →
LGG	DFS	Median	All	0.673	0.785	.002	12	view →
SKCM	OS	Tertile	IV	1.000	0.238	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SMC2-AS1–ACC (OS)

Open the ACC breakdown →