SMC2-AS1

Across TCGA pan-cancer cohorts, SMC2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SMC2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SMC2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SMC2-AS1 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and LUAD are the cancer types where SMC2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMC2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−0.702	.013	8	view →
KIRC	All	II,III,IV	−0.035	.011	8	view →
LUAD	Female	II,III,IV	−0.262	<.001	7	view →
LIHC	Male	All	+0.030	<.001	7	view →
LUSC	All	All	−0.185	<.001	6	view →
KICH	All	All	−0.122	<.001	5	view →
UCEC	All	All	−0.406	<.001	4	view →
COAD	Male	II,III,IV	−0.165	.006	4	view →
HNSC	All	All	−0.098	.013	3	view →
CHOL	All	All	+0.096	.002	3	view →
STAD	All	All	−0.165	.018	2	view →
PRAD	All	All	−0.053	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SMC2-AS1–BLCA

Open the BLCA breakdown →