SMC1B

Across TCGA patient cohorts, SMC1B mutation is significantly associated with the RNA expression of many other genes, with 6,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC1B-associated genes across cancer lineages are COX15, DONSON, and APEH. Each is linked with SMC1B in more than 3 cancer types. Because this analysis shows association rather than direction, both SMC1B-to-partner and partner-to-SMC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by SMC1B-low versus SMC1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1B→partner) and Y-score (partner→SMC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.408	+1.857	<.001	<.001	3	4
UCEC	DONSON →	+0.476	+3.202	<.001	<.001	3	4
UCEC	APEH →	+0.379	+1.857	.002	<.001	3	4
UCEC	IDH3A →	+0.479	+3.108	<.001	<.001	3	4
UCEC	LEO1 →	+0.438	+1.868	<.001	<.001	3	4
UCEC	RRM1 →	+0.816	+2.099	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,019 associations by consensus.

COX15 by SMC1B expression — UCEC

Explore this box plot interactively →