SMC1B

Across TCGA pan-cancer cohorts, SMC1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SMC1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SMC1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMC1B is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where SMC1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMC1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.166	<.001	9	view →
HNSC	All	II,III,IV	+0.601	.003	8	view →
BLCA	All	III,IV	+1.249	.004	7	view →
LUAD	Male	All	+1.033	<.001	7	view →
LIHC	Male	All	+0.429	<.001	7	view →
LUSC	All	All	+0.858	<.001	6	view →
BRCA	All	II,III,IV	+0.621	<.001	6	view →
STAD	All	All	+0.520	.001	5	view →
UCEC	All	All	+0.599	.009	2	view →
CHOL	All	All	+0.470	.001	2	view →
KICH	Female	III,IV	+0.310	.047	2	view →
PAAD	Male	All	−0.109	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SMC1B–KIRC

Open the KIRC breakdown →