SMC1B

Across TCGA patient cohorts, SMC1B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC1B-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and c-Kit. Each is linked with SMC1B in more than 3 cancer types. Because this analysis shows association rather than direction, both SMC1B-to-partner and partner-to-SMC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SMC1B-low versus SMC1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1B→partner) and Y-score (partner→SMC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.686	+2.522	<.001	<.001	3	4
STAD	ASNS →	+0.452	+3.321	.030	.010	3	3
SKCM	c-Kit →	-0.731	-2.584	.015	.011	3	2
COAD	Bad_pS112 →	-0.229	-3.161	.018	.019	3	2
UCEC	ERK2 →	+0.141	+1.584	.026	.032	3	2
UCEC	MEK1 →	+0.339	+1.652	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by SMC1B expression — UCEC

Explore this box plot interactively →