SMC1B

Across TCGA cell cohorts, SMC1B mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC1B-associated genes across cancer lineages are OR7G3, ZBTB49, and C16orf90. Each is linked with SMC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC1B-to-partner and partner-to-SMC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7G3 grouped by SMC1B-low versus SMC1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1B→partner) and Y-score (partner→SMC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR7G3 →	+0.027	+4.384	<.001	.006	3	2
LARGE_INTESTINE	ZBTB49 →	+0.490	+3.067	<.001	.009	3	2
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
BLOOD_Leukemia	ACAN →	+0.137	+4.242	<.001	.002	3	1
BLOOD_Leukemia	MAGEC3 →	+0.219	+3.855	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

OR7G3 by SMC1B expression — BLOOD_Leukemia

Explore this box plot interactively →