SMC1A

Across TCGA pan-cancer cohorts, SMC1A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SMC1A data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMC1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMC1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LIHC are the cancer types where SMC1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.334	0.771	<.001	48	view →
UCEC	DFS	Median	II,III,IV	0.921	0.417	.001	34	view →
LIHC	DFS	Median	All	0.090	0.535	<.001	30	view →
UCS	OS	Median	All	0.135	0.687	.009	24	view →
READ	OS	Median	III,IV	0.111	0.903	<.001	21	view →
COAD	OS	Median	III,IV	0.208	0.791	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SMC1A–HNSC (OS)

Open the HNSC breakdown →