SMC1A

Across TCGA pan-cancer cohorts, SMC1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SMC1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMC1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMC1A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where SMC1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMC1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.938	<.001	11	view →
COAD	Male	All	+0.661	<.001	10	view →
LIHC	Female	II,III,IV	+1.121	<.001	9	view →
STAD	Male	II,III,IV	+1.255	<.001	8	view →
THCA	All	II,III,IV	−0.676	<.001	8	view →
LUSC	Male	II,III,IV	+0.898	<.001	7	view →
BLCA	Female	All	+0.991	<.001	6	view →
BRCA	All	II,III,IV	+0.547	<.001	6	view →
CHOL	All	All	+1.514	<.001	5	view →
LUAD	All	All	+0.381	<.001	5	view →
ESCA	All	All	+0.972	.006	2	view →
READ	All	All	+0.527	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SMC1A–HNSC

Open the HNSC breakdown →