SMC1A

Across TCGA pan-cancer cohorts, SMC1A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SMC1A data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMC1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMC1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where SMC1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.258	1.000	.017	19	view →
LSCC	OS	Quartile	II,III,IV	0.929	0.536	.027	7	view →
CCRCC	DFS	Tertile	III,IV	0.788	0.423	.015	7	view →
GBM	OS	Quartile	All	0.576	0.290	.004	6	view →
LUAD	OS	Median	III,IV	0.807	0.430	.018	5	view →
PDAC	OS	Median	IV	0.962	0.488	.048	3	view →
UCEC	OS	Tertile	All	0.887	0.976	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SMC1A–HNSC (OS)

Open the HNSC breakdown →