SMC1A

Across TCGA patient cohorts, SMC1A protein abundance is significantly associated with the RNA expression of many other genes, with 22,679 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC1A-associated genes across cancer lineages are MSL2, VRK1, and PCIF1. Each is linked with SMC1A in more than 8 cancer types. Because this analysis shows association rather than direction, both SMC1A-to-partner and partner-to-SMC1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMC1A versus MSL2 in HNSC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1A→partner) and Y-score (partner→SMC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSL2 →	+0.660	+0.191	<.001	<.001	3	9
HNSC	VRK1 →	+0.783	+0.197	.001	<.001	3	8
HNSC	PCIF1 →	+0.711	+0.248	<.001	<.001	3	8
HNSC	SMC3 →	+0.713	+0.233	.003	<.001	3	8
LSCC	TGIF2 →	+0.771	+0.310	<.001	<.001	3	8
LSCC	TMPO →	+0.795	+0.235	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,679 associations by consensus.

SMC1A vs MSL2 — HNSC

Explore this scatter interactively →