SMC1A

Across TCGA patient cohorts, SMC1A mutation is significantly associated with the RNA expression of many other genes, with 4,670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC1A-associated genes across cancer lineages are ENTR1, FAM210A, and AP2B1. Each is linked with SMC1A in more than 2 cancer types. Because this analysis shows association rather than direction, both SMC1A-to-partner and partner-to-SMC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTR1 grouped by SMC1A-low versus SMC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1A→partner) and Y-score (partner→SMC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENTR1 →	+0.380	+1.828	<.001	<.001	3	3
UCEC	FAM210A →	+0.246	+1.394	.008	.004	3	3
UCEC	AP2B1 →	+0.328	+1.455	.001	.001	3	3
CESC	TRAJ11 →	+0.481	+3.475	<.001	.008	3	3
COAD	HMGN2P32 →	+0.568	+2.267	<.001	.002	3	3
COAD	ATP5MGP7 →	+0.098	+2.627	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,670 associations by consensus.

ENTR1 by SMC1A expression — UCEC

Explore this box plot interactively →