SMC1A

Across TCGA patient cohorts, SMC1A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC1A-associated genes across cancer lineages are Lck, YB-1, and S6_pS240_S244. Each is linked with SMC1A in more than 2 cancer types. Because this analysis shows association rather than direction, both SMC1A-to-partner and partner-to-SMC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SMC1A-low versus SMC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1A→partner) and Y-score (partner→SMC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.125	+1.129	.014	.006	3	3
BLCA	YB-1 →	+0.185	+1.891	.020	.030	3	2
COAD	S6_pS240_S244 →	+0.424	+2.820	.017	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.155	+2.330	.001	.020	3	2
COAD	C-Raf →	+0.144	+3.467	.029	.002	3	2
UCEC	eEF2 →	+0.201	+0.874	.027	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Lck by SMC1A expression — UCEC

Explore this box plot interactively →