SMC1A

Across TCGA cell cohorts, SMC1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,821 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMC1A-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Negative regulation of cell cycle process, and Positive regulation of mitotic cytokinesis. Each is linked with SMC1A in more than 19 cancer types. Because this analysis shows association rather than direction, both SMC1A-to-partner and partner-to-SMC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by SMC1A-low versus SMC1A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1A→partner) and Y-score (partner→SMC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.201	+1.230	<.001	<.001	3	20
PANCREAS	Negative regulation of cell cycle process →	+0.068	+1.798	<.001	<.001	3	20
BONE	Positive regulation of mitotic cytokinesis →	+0.177	+1.676	.007	<.001	3	19
SOFT_TISSUE	DNA strand elongation →	+0.149	+1.323	<.001	<.001	3	19
KIDNEY	Regulation of sister chromatid segregation →	+0.130	+1.370	<.001	<.001	3	19
SOFT_TISSUE	Positive regulation of cell cycle →	+0.082	+1.238	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,821 associations by consensus.

DNA strand elongation involved in DNA replication by SMC1A expression — SOFT_TISSUE

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