SMC1A

Across TCGA cell cohorts, SMC1A mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC1A-associated genes across cancer lineages are CENPVL1, OR1L3, and TRAPPC3L. Each is linked with SMC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC1A-to-partner and partner-to-SMC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by SMC1A-low versus SMC1A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC1A→partner) and Y-score (partner→SMC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CENPVL1 →	+0.177	+2.971	.006	.003	3	2
BLOOD_Lymphoma	OR1L3 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TRAPPC3L →	+0.138	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	OR56A1 →	+0.046	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OR52L1 →	+0.074	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	OR56A4 →	+0.074	+4.927	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

CENPVL1 by SMC1A expression — BLOOD_Leukemia

Explore this box plot interactively →