SMARCE1

Across TCGA patient cohorts, SMARCE1 mutation is significantly associated with the RNA expression of many other genes, with 2,801 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCE1-associated genes across cancer lineages are RNA5SP146, SLC25A5P9, and MTND5P35. Each is linked with SMARCE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCE1-to-partner and partner-to-SMARCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP146 grouped by SMARCE1-low versus SMARCE1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCE1→partner) and Y-score (partner→SMARCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP146 →	+0.749	+4.787	<.001	.003	3	3
SKCM	SLC25A5P9 →	+0.051	+4.208	<.001	.003	3	2
CESC	MTND5P35 →	+0.021	+4.539	<.001	.008	3	2
UCEC	RNU1-17P →	+0.248	+2.272	<.001	.002	3	2
UCEC	RNA5SP424 →	+0.141	+2.242	.007	.005	3	2
UCEC	NOL8P1 →	+0.034	+2.327	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,801 associations by consensus.

RNA5SP146 by SMARCE1 expression — LUAD

Explore this box plot interactively →