SMARCE1

Across TCGA pan-cancer cohorts, SMARCE1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SMARCE1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SMARCE1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMARCE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

KIRP, UCEC, and BRCA are the cancer types where SMARCE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	IV	0.034	0.527	<.001	61	view →
UCEC	DFS	Tertile	II,III,IV	0.909	0.755	.002	56	view →
BRCA	DFS	Median	All	0.965	0.931	.001	50	view →
LGG	OS	Median	All	0.753	0.870	<.001	48	view →
DLBC	OS	Median	III,IV	0.153	0.797	.002	41	view →
ACC	DFS	Median	All	0.536	0.893	<.001	41	view →
LUAD	OS	Tertile	II,III,IV	0.459	0.177	.002	33	view →
LIHC	DFS	Median	All	0.474	0.607	.001	32	view →
KIRC	DFS	Quartile	III,IV	0.536	0.267	.018	24	view →
SCLC	DFS	Median	II,III,IV	0.552	0.169	.001	21	view →
UCS	DFS	Quartile	II,III,IV	0.595	0.153	.025	20	view →
CHOL	DFS	Tertile	III,IV	0.172	0.779	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SMARCE1–KIRP (DFS)

Open the KIRP breakdown →