SMARCE1

Across TCGA patient cohorts, SMARCE1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCE1-associated genes across cancer lineages are mTOR_pS2448, p27_pT198, and ATM. Each is linked with SMARCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCE1-to-partner and partner-to-SMARCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SMARCE1-low versus SMARCE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCE1→partner) and Y-score (partner→SMARCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.146	-1.980	.015	.030	3	2
UCEC	p27_pT198 →	+0.128	+3.700	.002	.001	3	2
UCEC	ATM →	-0.505	-1.906	.005	.016	3	2
UCEC	4E-BP1 →	+0.439	+3.730	<.001	<.001	3	2
UCEC	eIF4E →	+0.198	+2.335	.019	.018	3	1
UCEC	FoxM1 →	+0.235	+2.415	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by SMARCE1 expression — UCEC

Explore this box plot interactively →