SMARCD3

Across TCGA patient cohorts, SMARCD3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCD3-associated genes across cancer lineages are ATM, Bcl-2, and eIF4E. Each is linked with SMARCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCD3-to-partner and partner-to-SMARCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SMARCD3-low versus SMARCD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCD3→partner) and Y-score (partner→SMARCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.448	-1.678	.009	.023	3	2
COAD	Bcl-2 →	+0.519	+2.815	<.001	.036	3	1
UCEC	eIF4E →	+0.233	+3.472	.003	.002	3	1
UCEC	GAPDH →	+0.532	+2.000	.009	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.175	-2.584	.006	.010	3	1
UCEC	JNK2 →	+0.181	+1.678	.017	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by SMARCD3 expression — UCEC

Explore this box plot interactively →