SMARCD3

Across TCGA pan-cancer cohorts, SMARCD3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SMARCD3 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SMARCD3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMARCD3 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUAD show a favorable association.

UVM, KIRC, and COAD are the cancer types where SMARCD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.384	0.879	<.001	142	view →
KIRC	DFS	Tertile	All	0.526	0.712	<.001	134	view →
COAD	DFS	Median	All	0.415	0.574	.002	53	view →
HNSC	DFS	Median	All	0.648	0.742	.001	42	view →
UCEC	DFS	Quartile	All	0.792	0.906	.003	40	view →
CESC	DFS	Median	IV	0.733	0.307	.003	36	view →
LUAD	OS	Quartile	All	0.862	0.718	<.001	19	view →
LIHC	OS	Quartile	II,III,IV	0.474	0.831	<.001	19	view →
PCPG	DFS	Median	All	0.619	0.931	.001	14	view →
CHOL	OS	Quartile	II,III,IV	0.750	0.159	.004	12	view →
ESCA	OS	Tertile	IV	0.143	0.674	.024	12	view →
ACC	OS	Quartile	III,IV	0.389	0.648	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SMARCD3–UVM (OS)

Open the UVM breakdown →