SMARCD3

Across TCGA cell cohorts, SMARCD3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCD3-associated genes across cancer lineages are TSLP, HSFY2, and OR10W1. Each is linked with SMARCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCD3-to-partner and partner-to-SMARCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSLP grouped by SMARCD3-low versus SMARCD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCD3→partner) and Y-score (partner→SMARCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSLP →	+0.469	+3.465	<.001	.002	3	1
LARGE_INTESTINE	HSFY2 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	RAX2 →	+0.052	+2.518	.003	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+2.669	<.001	.004	3	1
LARGE_INTESTINE	FOXD4L1 →	+0.280	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TSLP by SMARCD3 expression — LARGE_INTESTINE

Explore this box plot interactively →