SMARCC2

Across TCGA cell cohorts, SMARCC2 mutation is significantly associated with the RNA expression of many other genes, with 178 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMARCC2-associated genes across cancer lineages are KHDC3L, GPR101, and GPR139. Each is linked with SMARCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCC2-to-partner and partner-to-SMARCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by SMARCC2-low versus SMARCC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC2→partner) and Y-score (partner→SMARCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.196	+3.096	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	GPR139 →	+0.076	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	CNGA2 →	+0.066	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PRR30 →	+0.036	+4.736	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

KHDC3L by SMARCC2 expression — BLOOD_Leukemia

Explore this box plot interactively →