SMARCC1

Across TCGA patient cohorts, SMARCC1 mutation is significantly associated with the RNA expression of many other genes, with 4,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCC1-associated genes across cancer lineages are ECHS1, SUV39H1, and RCC1. Each is linked with SMARCC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMARCC1-to-partner and partner-to-SMARCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by SMARCC1-low versus SMARCC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC1→partner) and Y-score (partner→SMARCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ECHS1 →	+0.404	+2.757	.002	.003	3	4
SKCM	SUV39H1 →	+0.577	+3.839	<.001	<.001	3	3
SKCM	RCC1 →	+0.630	+3.331	.001	.005	3	3
UCEC	EMC3-AS1 →	+0.535	+2.828	<.001	<.001	3	3
SKCM	MRPS23 →	+0.469	+2.757	.006	.003	3	3
UCEC	DRG1 →	+0.280	+4.031	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,689 associations by consensus.

ECHS1 by SMARCC1 expression — SKCM

Explore this box plot interactively →