SMARCAL1-AS1

Across TCGA pan-cancer cohorts, SMARCAL1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SMARCAL1-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SMARCAL1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMARCAL1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and OV show a favorable association.

KICH, LUAD, and KIRP are the cancer types where SMARCAL1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.832	0.976	<.001	126	view →
LUAD	DFS	Quartile	All	0.136	0.390	<.001	90	view →
KIRP	DFS	Quartile	II,III,IV	0.117	0.615	<.001	78	view →
READ	DFS	Tertile	II,III,IV	0.131	0.734	<.001	54	view →
SKCM	OS	Median	All	0.405	0.236	<.001	32	view →
ACC	DFS	Tertile	All	0.142	0.603	.011	22	view →
OV	OS	Median	III,IV	0.723	0.653	.016	18	view →
COAD	DFS	Tertile	IV	0.226	0.518	.011	18	view →
PAAD	DFS	Quartile	All	0.549	0.284	.011	14	view →
CHOL	DFS	Tertile	All	0.827	0.266	.035	9	view →
THCA	OS	Tertile	II,III,IV	0.927	0.979	.031	9	view →
SARC	OS	Tertile	All	0.847	0.512	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SMARCAL1-AS1–KICH (OS)

Open the KICH breakdown →