SMARCA5

Across TCGA cell cohorts, SMARCA5 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMARCA5-associated genes across cancer lineages are MS4A14, HTN3, and XAGE3. Each is linked with SMARCA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCA5-to-partner and partner-to-SMARCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A14 grouped by SMARCA5-low versus SMARCA5-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA5→partner) and Y-score (partner→SMARCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	HTN3 →	+0.076	+4.736	<.001	.009	3	2
OESOPHAGUS	XAGE3 →	+0.163	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1
OESOPHAGUS	C2orf83 →	+0.020	+4.906	<.001	.006	3	1
BLOOD_Leukemia	ITIH6 →	+0.024	+4.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MS4A14 by SMARCA5 expression — OESOPHAGUS

Explore this box plot interactively →