SMARCA5-AS1

Across TCGA pan-cancer cohorts, SMARCA5-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SMARCA5-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SMARCA5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMARCA5-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

UVM, MESO, and UCS are the cancer types where SMARCA5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.382	0.707	<.001	99	view →
MESO	OS	Quartile	IV	0.191	0.724	.001	68	view →
UCS	OS	Median	II,III,IV	0.800	0.437	.003	62	view →
KIRP	DFS	Median	All	0.495	0.687	<.001	51	view →
LUSC	DFS	Tertile	III,IV	0.183	0.749	.008	38	view →
UCEC	DFS	Quartile	All	0.932	0.866	.014	22	view →
LIHC	DFS	Tertile	All	0.175	0.329	.001	21	view →
KIRC	DFS	Median	All	0.738	0.519	.001	19	view →
ACC	DFS	Median	IV	0.472	0.089	.012	15	view →
CESC	DFS	Quartile	All	0.377	0.629	.014	12	view →
PRAD	OS	Quartile	All	0.974	1.000	.027	12	view →
THCA	DFS	Quartile	III,IV	0.686	0.905	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SMARCA5-AS1–UVM (DFS)

Open the UVM breakdown →