SMARCA5-AS1

Across TCGA pan-cancer cohorts, SMARCA5-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SMARCA5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMARCA5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMARCA5-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where SMARCA5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMARCA5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.113	<.001	10	view →
THCA	All	All	−0.113	<.001	9	view →
LIHC	All	II,III,IV	+0.037	<.001	8	view →
COAD	All	II,III,IV	+0.170	<.001	6	view →
KIRC	Male	II,III,IV	−0.075	<.001	6	view →
LUAD	All	II,III,IV	−0.173	.001	4	view →
KICH	All	II,III,IV	−0.134	.001	4	view →
LUSC	Male	All	−0.111	<.001	4	view →
STAD	Male	II,III,IV	+0.168	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SMARCA5-AS1–HNSC

Open the HNSC breakdown →