SMARCA4

Across TCGA pan-cancer cohorts, SMARCA4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SMARCA4 data layer compared with 26 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMARCA4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMARCA4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where SMARCA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.605	0.838	.003	35	view →
LSCC	OS	Tertile	All	0.935	0.711	.006	25	view →
CCRCC	OS	Median	All	0.659	0.957	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SMARCA4–HNSC (OS)

Open the HNSC breakdown →