SMARCA4

Across TCGA pan-cancer cohorts, SMARCA4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SMARCA4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMARCA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMARCA4 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

COAD, BLCA, and THCA are the cancer types where SMARCA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMARCA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.398	<.001	11	view →
BLCA	Male	All	+1.189	<.001	11	view →
THCA	Female	II,III,IV	+0.538	<.001	10	view →
LIHC	Female	II,III,IV	+1.903	<.001	9	view →
STAD	Male	II,III,IV	+1.390	<.001	8	view →
LUSC	Male	II,III,IV	+1.193	<.001	7	view →
UCEC	All	All	+1.162	<.001	6	view →
BRCA	All	II,III,IV	+0.869	<.001	6	view →
HNSC	Male	All	+0.750	<.001	6	view →
KIRC	Male	II,III,IV	−0.382	.003	6	view →
CHOL	Female	All	+3.356	<.001	5	view →
KIRP	Female	All	+0.456	.013	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SMARCA4–COAD

Open the COAD breakdown →