SMARCA4

Across TCGA patient cohorts, SMARCA4 mutation is significantly associated with the RNA expression of many other genes, with 7,350 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SMARCA4-associated genes across cancer lineages are NCAPG, DEPDC1, and ARHGAP11A. Each is linked with SMARCA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMARCA4-to-partner and partner-to-SMARCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by SMARCA4-low versus SMARCA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA4→partner) and Y-score (partner→SMARCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCAPG →	+0.870	+2.754	<.001	<.001	3	6
LUAD	DEPDC1 →	+0.777	+2.058	<.001	<.001	3	6
LUAD	ARHGAP11A →	+0.761	+4.023	<.001	<.001	3	6
LUAD	RAD51 →	+0.908	+2.378	<.001	<.001	3	6
LUAD	TIPIN →	+0.305	+1.594	.003	.004	3	6
LUAD	PLAT →	-1.203	-2.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,350 associations by consensus.

NCAPG by SMARCA4 expression — LUAD

Explore this box plot interactively →