SMARCA4

Across TCGA patient cohorts, SMARCA4 mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCA4-associated genes across cancer lineages are mTOR_pS2448, TFRC, and Cyclin-B1. Each is linked with SMARCA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMARCA4-to-partner and partner-to-SMARCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SMARCA4-low versus SMARCA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA4→partner) and Y-score (partner→SMARCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.190	-2.402	.005	.003	3	5
LUAD	TFRC →	+0.613	+2.584	.001	.009	3	5
LUAD	Cyclin-B1 →	+0.499	+2.115	.004	.017	3	5
UCEC	PRAS40_pT246 →	+0.112	+1.289	.010	.021	3	5
STAD	p90 RSK →	+0.335	+3.459	<.001	.004	3	4
COAD	Rad50 →	-0.266	-3.321	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

mTOR_pS2448 by SMARCA4 expression — LUAD

Explore this box plot interactively →