SMARCA4

Across TCGA cell cohorts, SMARCA4 mutation is significantly associated with the RNA expression of many other genes, with 3,193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCA4-associated genes across cancer lineages are KIAA0895, KBTBD6, and SNUPN. Each is linked with SMARCA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMARCA4-to-partner and partner-to-SMARCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA0895 grouped by SMARCA4-low versus SMARCA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA4→partner) and Y-score (partner→SMARCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIAA0895 →	+0.754	+3.169	.003	.006	3	4
OVARY	KBTBD6 →	+0.820	+3.169	<.001	.005	3	4
LUNG_NSCLC_LUAD	SNUPN →	+0.492	+1.875	<.001	.002	3	4
OVARY	PER1 →	+1.023	+3.074	.001	.008	3	4
OVARY	GAS2L1 →	+1.252	+2.350	<.001	.008	3	4
OVARY	ALKBH2 →	+0.763	+3.395	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,193 associations by consensus.

KIAA0895 by SMARCA4 expression — LARGE_INTESTINE

Explore this box plot interactively →