SMAD6

Across TCGA cell cohorts, SMAD6 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMAD6-associated genes across cancer lineages are SSX7, NPHS2, and KCNK17. Each is linked with SMAD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD6-to-partner and partner-to-SMAD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX7 grouped by SMAD6-low versus SMAD6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD6→partner) and Y-score (partner→SMAD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SSX7 →	+0.013	+4.078	<.001	.009	3	1
LARGE_INTESTINE	NPHS2 →	+0.062	+3.029	.006	.003	3	1
LARGE_INTESTINE	KCNK17 →	+0.064	+2.906	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.206	+3.425	.004	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.135	+2.892	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SSX7 by SMAD6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →