SMAD5

Across TCGA patient cohorts, SMAD5 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD5-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with SMAD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD5-to-partner and partner-to-SMAD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SMAD5-low versus SMAD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD5→partner) and Y-score (partner→SMAD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.541	-2.893	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.097	-1.738	.002	.011	3	1
UCEC	EGFR_pY1068 →	-0.253	-1.847	.001	.007	3	1
UCEC	eIF4E →	+0.240	+2.754	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.101	-1.362	.008	.034	3	1
UCEC	ERK2 →	+0.183	+1.906	.002	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by SMAD5 expression — UCEC

Explore this box plot interactively →