SMAD5

Across TCGA cell cohorts, SMAD5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,033 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMAD5-associated GO terms across cancer lineages are Positive regulation of mRNA catabolic process, Centriole-centriole cohesion, and Peptidyl-serine phosphorylation. Each is linked with SMAD5 in more than 14 cancer types. Because this analysis shows association rather than direction, both SMAD5-to-partner and partner-to-SMAD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA catabolic process grouped by SMAD5-low versus SMAD5-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD5→partner) and Y-score (partner→SMAD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of mRNA catabolic process →	+0.062	+1.010	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Centriole-centriole cohesion →	+0.093	+1.239	<.001	<.001	3	14
OESOPHAGUS	Peptidyl-serine phosphorylation →	+0.069	+0.976	.001	<.001	3	14
BONE	Negative regulation of microtubule depolymerization →	+0.110	+0.772	<.001	<.001	3	14
BLOOD_Leukemia	Negative regulation of beige fat cell differentiation →	+0.074	+0.843	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.082	+1.067	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,033 associations by consensus.

Positive regulation of mRNA catabolic process by SMAD5 expression — BLOOD_Lymphoma

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